BRAF mutation in papillary thyroid microcarcinoma – additional marker of risk stratification
نویسندگان
چکیده
منابع مشابه
Preoperative BRAF Mutation is Predictive of Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma
Thyroid cancer is the most common endocrine malignancy, accounting for 1% of all malignant tumors in the USA (Sherman, 2003) and 5.9% in one district of Wenzhou (a coastal city in Southeast China, with a incidence of 21/100,000) (Zheng and Zhang, 2007). The incidence of papillary thyroid carcinoma, which is the most common histologic type of thyroid malignancy, is increasing worldwide (Davies a...
متن کاملBRAF mutation in papillary thyroid carcinoma.
BRAF mutation is the most common genetic alternation in thyroid cancer, particularly in papillary thyroid cancer (PTC). Excessive activation of BRAF/MAPK signaling pathway due to BRAF mutation plays a central role in the tumorigenesis and development of PTC. The association of BRAF mutation with poor clinicopathological characteristics of PTC further demonstrated the importance of the BRAF muta...
متن کاملPredicting Extrathyroidal Extension in Patients With Papillary Thyroid Microcarcinoma According to a BRAF Mutation
OBJECTIVES The aim of this study was to evaluate the association between preoperative parameters and extrathyroidal extension (ETE) of papillary thyroid microcarcinoma (PTMC) according to the BRAF mutation and to evaluate the preoperative predictability of ETE. METHODS We analyzed the medical records of 332 patients with PTMC (140 in the BRAF- group and 192 in the BRAF+ group). The presence o...
متن کاملPapillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings.
BACKGROUND Papillary thyroid microcarcinoma (PMC; <or=1 cm) is thought to take a benign course during the lifetime. However, recent studies showed high recurrence rates for PMC. METHODS We analyzed the clinicopathological features, long-term prognosis, and some molecular characteristics including BRAF(V600E) mutation by retrospectively reviewing the records of 1150 patients with papillary thy...
متن کاملThe BRAF(V600E) mutation in papillary thyroid microcarcinoma: does the mutation have an impact on clinical outcome?
CONTEXT An activating mutation in the gene BRAF has been correlated with poorer prognosis and more aggressive clinical course in papillary thyroid carcinoma (PTC). We therefore hypothesized that the good prognosis, high 5-year disease-free rate and high survival rate of patients with less aggressive papillary thyroid microcarcinoma (pT1aNo-x) would be associated with a lower incidence of the BR...
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ژورنال
عنوان ژورنال: Clinical and experimental thyroidology
سال: 2014
ISSN: 2310-3787,1995-5472
DOI: 10.14341/ket2014336-40